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New England, the 1960s. 17-year-old Susanna (Winona Ryder) is diagnosed as suffering a borderline personality disorder and sent to Claymore psychiatric hospital. Once there, she rejects the treatment of psychiatrist Dr Wick (Vanessa Redgrave) and nurse Valerie (Whoopi Goldberg), turning instead to her fellow inmates - the disruptive Lisa (Angelina Jolie), compulsive liar Georgina (Clea DuVall), and spoilt rich girl Daisy (Brittany Murphy), who suffers from an eating disorder.